🔥 Fat Loss & Metabolism: Top Research Peptides for 2025

In the evolving world of metabolic science, researchers are turning to peptides to explore targeted fat loss, appetite regulation, and metabolic optimisation. As obesity and insulin resistance become global health priorities, the peptides being studied today could shape the next decade of treatment strategies.

Here are the leading research peptides for fat loss and metabolic performance in 2025.

🧬 Why Peptides for Fat Loss?

Peptides offer targeted signalling, often mimicking hormones that control:

• Appetite and satiety

• Fat breakdown (lipolysis)

• Insulin sensitivity and glucose control

• Energy metabolism and mitochondrial function

They’re designed to stimulate natural biological responses — making them powerful tools in obesity, fasting-mimicry, and recomposition research.

🔝 Top Fat Loss Peptides in 2025 Research

🔹 Tesofensine (500mcg)

Goal: Appetite suppression and mood elevationTesofensine modulates dopamine, norepinephrine, and serotonin — showing impressive appetite control and fat loss potential in clinical trials.

• Oral, non-stimulant format

• Improves motivation and focus

• Often compared to stimulant-like effects, without the crash

🔹 Semaglutide (GLP-1 Agonist)

Goal: Appetite regulation, delayed gastric emptyingSemaglutide mimics GLP-1, a hormone that promotes satiety, reduces blood sugar, and slows digestion — leading to substantial weight reduction in trials.

• Weekly injectable format

• Used in diabetes and obesity research

• May improve insulin sensitivity + reduce cravings

  
  

🔹 Tirzepatide (GIP + GLP-1 Dual Agonist)

Goal: Dual incretin effect for superior fat lossThis dual-acting peptide outperforms semaglutide in many studies, offering enhanced metabolic modulation and appetite suppression.

• Studied for 30–40 lbs+ fat reduction over 12+ weeks

• Investigated for cardiometabolic protection and insulin control

• Game-changing compound in weight loss research

  
  

🔹 AOD-9604 (HGH Fragment 176–191)

Goal: Targeted lipolysis without GH side effectsAOD-9604 is a fragment of the HGH molecule being researched for its fat-burning capabilities, without influencing IGF-1 levels or causing growth-related side effects.

• Focused on abdominal fat loss

• Used in recomposition studies

• Mild on blood sugar and hormone levels

  
  

🔹 5-Amino-1MQ

Goal: Metabolic reprogramming via NNMT inhibitionThis novel compound targets nicotinamide N-methyltransferase (NNMT) to increase NAD+ levels, improve mitochondrial function, and boost fat metabolism.

• Under study for fat mass reduction + energy improvement

• Also explored in longevity + metabolic dysfunction research

• Often stacked with MOTS-c or CJC-1295

  
  

🔹 CJC-1295 + Ipamorelin

Goal: GH pulse stimulation & metabolic supportThis growth hormone-releasing peptide combo supports fat oxidation, sleep recovery, and lean mass preservation — making it ideal for fasted protocols or post-cut recovery.

• Long-acting growth hormone support

• Improves sleep, recovery, and metabolism

• Used in lean recomp research

  
  

🧠 Example Research Stack (For Fat Loss Focus)

Cycle (for study purposes only):

• AM: Tesofensine 500mcg + AOD-9604

• PM: CJC-1295 + Ipamorelin

• Add-on (Weekly): Semaglutide or Tirzepatide (based on model type)

• Advanced support: 5-Amino-1MQ for mitochondrial modulation

  
  

⚠️ Reminder: For Research Use Only

All peptides listed are provided by PeptideX strictly for research and laboratory purposes.They are not for human consumption, clinical use, or therapeutic application.

Always follow local guidelines and lab safety protocols.